Redesigning the rules of compatibilityTM

We’re building a universal donor cell platform designed to enable scalable, immune-compatible, off-the-shelf allogeneic therapies for cell and tissue transplantation.

About us

Altera Biosciences is a preclinical-stage biotechnology company developing a universal donor cell platform to power the next generation of off-the-shelf allogeneic cell therapies.

Our mission is to remove the barriers of immunogenicity and donor-matching through cell engineering — making cell therapy more scalable, accessible, and impactful across the globe.

We’re driven by a belief that advanced therapies should be designed for everyone — not just a few. That’s why we’re focused on creating foundational technologies that unlock long-term, off-the-shelf solutions for diverse patient populations.

Why Universal Donor Cells matter

The success of both cell-based and organ transplantation is often limited by one critical factor: immune compatibility. Whether in advanced therapies or life-saving transplants, patients typically require cells or organs that are immunologically matched — a process that depends on scarce donor availability, individualized preparation, and lifelong immunosuppression.

These limitations result in morbidity and mortality as a consequence of delayed treatments, high costs, and restricted access — particularly in low-resource or time-sensitive settings.

Universal donor cells represent a potential paradigm shift: engineered to be immune-compatible across recipients, they offer a path toward scalable, off-the-shelf cell and tissue therapies that bypass the need for matching or rejection-prone immunosuppressive regimens.

While this technology is still in early development, its long-term promise could help solve one of the most pressing challenges in transplantation: the lack of compatible donors. By building toward this future, we hope to help expand access to safe, timely, and effective treatment options for patients around the world.

Why Universal Donor Cells matter

The success of both cell-based and organ transplantation is often limited by one critical factor: immune compatibility. Whether in advanced therapies or life-saving transplants, patients typically require cells or organs that are immunologically matched — a process that depends on scarce donor availability, individualized preparation, and lifelong immunosuppression.

These limitations result in morbidity and mortality as a consequence of delayed treatments, high costs, and restricted access — particularly in low-resource or time-sensitive settings.

Universal donor cells represent a potential paradigm shift: engineered to be immune-compatible across recipients, they offer a path toward scalable, off-the-shelf cell and tissue therapies that bypass the need for matching or rejection-prone immunosuppressive regimens.

While this technology is still in early development, its long-term promise could help solve one of the most pressing challenges in transplantation: the lack of compatible donors. By building toward this future, we hope to help expand access to safe, timely, and effective treatment options for patients around the world.

Current:
The Status Quo

Future:
The Universal Donor Cell Platfrm

Our Science

Altera is leveraging the unlimited self-renewing capabilities of induced pluripotent stem cells (iPSCs) and advanced gene regulation technologies to build a novel universal donor cell platform.

Our goal is to help overcome one of the greatest challenges in transplantation and advanced therapies: the limited availability of immunologically compatible donors.

By engineering immune-compatible cells that can be used across recipients, we aim to enable scalable, off-the-shelf solutions that expand access to life-changing therapies.

Our Science

Altera is leveraging the unlimited self-renewing capabilities of induced pluripotent stem cells (iPSCs) and advanced gene regulation technologies to build a novel universal donor cell platform.

Our goal is to help overcome one of the greatest challenges in transplantation and advanced therapies: the limited availability of immunologically compatible donors.

By engineering immune-compatible cells that can be used across recipients, we aim to enable scalable, off-the-shelf solutions that expand access to life-changing therapies.

Leadership Team

Altera is led by a team of scientists and entrepreneurs with experience spanning cell therapy, gene regulation, and early-stage biotech. Together, we bring a shared commitment to advancing science that’s accessible, globally relevant, and built for real-world impact.
ALEXANDRA MISZEWSKI

Co-Founder & Chief Executive Officer

MICHAEL PEPPER, MBChB, PhD, MD

Co-Founder & Chief Scientific Officer

In The News

News 1

Copy to go here. Copy to go here. Copy to go here. Copy to go

News 2

Copy to go here. Copy to go here. Copy to go here. Copy to go

News 3

Copy to go here. Copy to go here. Copy to go here. Copy to go

About us

Altera Biosciences is a preclinical-stage biotechnology company developing a universal donor cell platform to power the next generation of off-the-shelf allogeneic cell therapies.

Our mission is to remove the barriers of immunogenicity and donor-matching through cell engineering — making cell therapy more scalable, accessible, and impactful across the globe.

We’re driven by a belief that advanced therapies should be designed for everyone — not just a few. That’s why we’re focused on creating foundational technologies that unlock long-term, off-the-shelf solutions for diverse patient populations.

Why Universal Donor Cells matter

The success of both cell-based and organ transplantation is often limited by one critical factor: immune compatibility. Whether in advanced therapies or life-saving transplants, patients typically require cells or organs that are immunologically matched — a process that depends on scarce donor availability, individualized preparation, and lifelong immunosuppression.

These limitations result in morbidity and mortality as a consequence of delayed treatments, high costs, and restricted access — particularly in low-resource or time-sensitive settings.

Universal donor cells represent a potential paradigm shift: engineered to be immune-compatible across recipients, they offer a path toward scalable, off-the-shelf cell and tissue therapies that bypass the need for matching or rejection-prone immunosuppressive regimens.

While this technology is still in early development, its long-term promise could help solve one of the most pressing challenges in transplantation: the lack of compatible donors. By building toward this future, we hope to help expand access to safe, timely, and effective treatment options for patients around the world.

Current:
The Status Quo

Future:
The Universal Donor Cell Platfrm

Our Science

Altera is leveraging the unlimited self-renewing capabilities of induced pluripotent stem cells (iPSCs) and advanced gene regulation technologies to build a novel universal donor cell platform.

Our goal is to help overcome one of the greatest challenges in transplantation and advanced therapies: the limited availability of immunologically compatible donors.

By engineering immune-compatible cells that can be used across recipients, we aim to enable scalable, off-the-shelf solutions that expand access to life-changing therapies.

Our Team

Altera is led by a team of scientists and entrepreneurs with experience spanning cell therapy, gene regulation, and early-stage biotech. Together, we bring a shared commitment to advancing science that’s accessible, globally relevant, and built for real-world impact.

ALEXANDRA MISZEWSKI

Co-Founder & CEO

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

MICHAEL PEPPER, MD, PhD

Co-Founder & Chief Scientific Officer

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

In The News

News 1

Copy to go here. Copy to go here. Copy to go here. Copy to go

News 2

Copy to go here. Copy to go here. Copy to go here. Copy to go

News 3

Copy to go here. Copy to go here. Copy to go here. Copy to go

About us

Altera Biosciences is a preclinical-stage biotechnology company developing a universal donor cell platform to power the next generation of off-the-shelf allogeneic cell therapies. Our mission is to remove the barriers of immunogenicity and donor-matching through cell engineering — making cell therapy more scalable, accessible, and impactful across the globe. We’re driven by a belief that advanced therapies should be designed for everyone — not just a few. That’s why we’re focused on creating foundational technologies that unlock long-term, off-the-shelf solutions for diverse patient populations.

Why Universal Donor Cells matter

The success of both cell-based and organ transplantation is often limited by one critical factor: immune compatibility. Whether in advanced therapies or life-saving transplants, patients typically require cells or organs that are immunologically matched — a process that depends on scarce donor availability, individualized preparation, and lifelong immunosuppression.

These limitations result in morbidity and mortality as a consequence of delayed treatments, high costs, and restricted access — particularly in low-resource or time-sensitive settings.

Universal donor cells represent a potential paradigm shift: engineered to be immune-compatible across recipients, they offer a path toward scalable, off-the-shelf cell and tissue therapies that bypass the need for matching or rejection-prone immunosuppressive regimens.

While this technology is still in early development, its long-term promise could help solve one of the most pressing challenges in transplantation: the lack of compatible donors. By building toward this future, we hope to help expand access to safe, timely, and effective treatment options for patients around the world.

Current:
The Status Quo

Future:
The Universal Donor Cell Platform

Our Science

Altera is leveraging the unlimited self-renewing capabilities of induced pluripotent stem cells (iPSCs) and advanced gene regulation technologies to build a novel universal donor cell platform. Our goal is to help overcome one of the greatest challenges in transplantation and advanced therapies: the limited availability of immunologically compatible donors. By engineering immune-compatible cells that can be used across recipients, we aim to enable scalable, off-the-shelf solutions that expand access to life-changing therapies.

Our Team

Altera is led by a team of scientists and entrepreneurs with experience spanning cell therapy, gene regulation, and early-stage biotech. Together, we bring a shared commitment to advancing science that’s accessible, globally relevant, and built for real-world impact.

ALEXANDRA MISZEWSKI

Co-Founder & CEO

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

MICHAEL PEPPER, MD, PhD

Co-Founder & Chief Scientific Officer

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

In The News

News 1

Copy to go here. Copy to go here. Copy to go here. Copy to go

News 2

Copy to go here. Copy to go here. Copy to go here. Copy to go

News 3

Copy to go here. Copy to go here. Copy to go here. Copy to go

Contact Us

Alexandra Miszewski

Co-Founder & Chief Executive Officer

After matriculating from Herschel Girls’ School in 2016, Alexandra Miszewski completed a Bachelor of Business Science in Finance at the University of Cape Town (UCT), followed by a Master’s in Finance, specialising in Investment Management, at the UCT Graduate School of Business.

In 2016, while still in high school, she co-founded Equinetendon.com — a sport horse rehabilitation company offering innovative solutions for soft tissue injuries, including the world’s first orthotic device for horses. The business grew from a small start-up into a company with a global presence and continues to operate successfully today.

In 2018, following a career-threatening injury to her own horse — and the failure of all existing treatment options — Alexandra co-founded Regenesis Vet. The company developed the world’s first commercially available systemic regenerative medicine treatment for horses, based on a proprietary autologous blood processing system. Today, the product is used in more than 15 countries across 5 continents.

She later founded Novita Biotechnology in June 2020, in the midst of the COVID-19 pandemic – a South African medical device company focused on developing affordable, high-quality regenerative and injectable products for both human and animal health. Novita is ISO 13485 certified and SAHPRA-registered, with a portfolio spanning the Orthopaedic, Aesthetic, and Veterinary sectors. Accessibility and affordability have been at the core of Novita’s mission, ensuring that niche medical devices reach those who need them most.

In 2024, Alexandra co-founded Altera Biosciences, a US-based biotech company developing a universal donor cell platform to address immune rejection in transplantation and cell therapy. While incorporated in the US, Altera maintains a strong South African footprint through its local subsidiary — the first dedicated cell and gene therapy company on the African continent.

Through her ventures, Alexandra has remained committed to building commercially viable solutions that expand access to advanced medical innovation. Her work reflects a broader vision: that scientific progress must be inclusive, affordable, and globally relevant — especially in regions often left behind.

She is also a competitive showjumper, regularly competing at the top level of the sport, and continues to advocate for women in leadership, science, and sport.

Professor Michael S. Pepper

MBChB (Cape Town), PhD (Geneva), MD (Geneva), Privat Docent (Geneva)

Michael Pepper has made significant contributions in cellular and molecular medicine to the fields of vascular biology and immunology. He has held prominent positions at both the Universities of Pretoria (UP) and Geneva (Switzerland). He is currently Director of the Institute for Cellular and Molecular Medicine, Director of the South African Medical Research Council Extramural Unit for Stem Cell Research and Therapy, and a Research Professor in the Department of Immunology in the Faculty of Health Sciences at UP. Michael obtained his MBChB in 1982 from the Faculty of Medicine at the University of Cape Town, and moved to Geneva in 1986, where he obtained his PhD in 1990, MD in 1992 and Privat Docent in 1997. He returned to South Africa in July 2004.

Michael led a consensus study for the Academy of Science of South Africa entitled “Human Genetics and Genomics in South Africa: Ethical, Legal and Social Implicaions” which was launched in December 2018. He is immediate past-President and Chairman of the Board of the South African Tissue Bank Association. Michael was co-responsible, together with Prof. Michele Ramsay, for co-ordinating the Southern African Human Genome Programme which was launched in January 2011. He has been working with the Department of Health on legislation pertaining to Chapter 8 of the National Health Act and the Medicines Act (and regulations thereto) since mid-2009. Michael was previously a member of the National Advisory Committee on Innovation (Project leader: “Bioeconomy Policies and Strategies”) which advises the Minister of Science and Technology and was also Chairperson of the National Biotech Advisory Committee.

Michael has 400 medical and scientific publications with an H-index of 79/97 (Scopus/Google Scholar). He is a member of the Academy of Science of South Africa and has received a numberof awards for his research including the South African Health Excellence Award for Scientific Excellence in 2019. His work has had an impact on the development of cell and gene therapies in South Africa, and he continues to be a leading figure in addressing ethical, legal, and social implications of research in these areas. Michael has been involved in the creation of several startup biotech companies including Next Biosciences, Transcure Bioservices and Antion Biosciences. In 2024 he cofounded Altera Biosciences and is Chief Scientic Officer.